R configuration is the spatial arrangement of R isomer. We have to check the atoms of the substituents one by one until a point of difference comes. If two substituents have directly bonded atoms with equal atomic numbers, then consider the atomic number of the next atom in those substituents.Therefore, if a substituent contains an atom with a high atomic number bonded directly to the chiral center, that substituent gets the higher priority than the others. When the atomic number is higher, the priority of it also gets higher. First, consider the atoms that directly bond to the chiral center.The basis for determining the priority of substituents attached to the chiral center is the CIP rules (Cahn-Ingold-Prelog rules). Thus, R isomer has its relative direction of the priority order in a clockwise direction. Side by Side Comparison РІР‚вЂњ R vs S Configuration in Tabular FormР”Р„n isomer is each of two or more compounds with the same formula but a different arrangement of atoms in the molecule. Similarities Between R and S ConfigurationР”Тђ. These substituents get listed according to their priority (the priority is determined using CIP rules as described below).Р”В¤. The R and S isomers are organic molecules having a chiral center, which is a carbon atom that has four different substituents attached to it. Here, the relative direction of the priority order is the descending order of priorities of substituents.

The key difference between R and S configuration is that the R configuration is the spatial arrangement of R isomer, which has its relative direction of priority order in a clockwise direction whereas S configuration is the spatial arrangement of S isomer that has its relative direction of priority order in an anticlockwise direction.

Difference between s and s